Comparing two lists with specific values to read

I have two lists

list1 = ['01:15', 'abc', '01:15', 'def', '01:45', 'ghi' ]
list2 = ['01:15', 'abc', '01:15', 'uvz', '01:45', 'ghi' ]

and when I loop through the list

list_difference = []
for item in list1:
    if item not in list2:
        list_difference.append(item)

and I managed to get the difference, but I need time as well because it is a separate item and 'uvz' does not mean to me anything in the list with a few thousand entries. I tried to convert it to the dictionary, but it overwrites with the last key:value {'01:15' : 'def'}.

Answer

reformat your data, then do whatever you have done before

list1=list(zip(list1[::2],list1[1::2]))
list2=list(zip(list2[::2],list2[1::2]))